Mystery of how plants make a family of medicinal molecules has been solved

This is a summary of: Lombe, B.

K.

et al .

Biosynthesis of cinchona alkaloids.

Nature https://doi.org/10.1038/s41586-026-10227-x (2026) .

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doi: https://doi.org/10.1038/d41586-026-00790-8
‘Expert opinion’ and the figure are published under a CC BY 4.0 licence.

Kaufman, T.

S.

& Rúveda, E.

A.

Angew.

Chem.

Int.

Edn 44 , 854–885 (2005).

Stork, G.

et al.

J.

Am.

Chem.

Soc.

123 , 3239–3242 (2001).

Leete, E.

Acc.

Chem.

Res.

2 , 59–64 (1969).

Trenti, F.

et al.

Org.

Lett.

23 , 1793–1797 (2021).

Lombe, B.

K., Zhou, T., Caputi, L., Ploss, K.

& O’Connor, S.

E.

Angew.

Chem.

Int.

Edn 64 , e202418306 (2025).

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