Astros vs. Guardians prediction, odds, time: 2026 MLB picks for Monday, April 20 from proven model

SportsLine's model simulated the Houston Astros vs.

Cleveland Guardians 10,000 times and revealed its MLB picks for Monday's matchup
First pitch is at 6:10 p.m.

ET from Progressive Field in Cleveland.

The Guardians have defeated Houston in four straight meetings.

The latest Guardians vs.

Astros odds list Cleveland as the -115 favorite on the money line (risk $115 to win $100), while the over/under for total runs is 7.5.

Before making any Astros vs.

Guardians picks or MLB predictions, be sure to see the Guardians vs.

Astros predictions and betting advice from SportsLine's proven computer model .

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Now, the model has set its sights on Guardians vs.

Astros and just locked in its picks and MLB predictions.

You can head to SportsLine now to see the model's picks .

Here are several MLB odds and betting lines for Astros vs.

Guardians:
Guardians vs.

Astros money line
Guardians vs.

Astros over/under
Guardians vs.

Astros run line
Guardians vs.

Astros picks
Guardians vs.

Astros streaming
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Top Astros vs.

Guardians predictions
After 10,000 simulations of Guardians vs.

Astros, the model is going Over 7.5 combined runs.

For over-under betting , no team has hit the Over more than Houston this year, with it sporting a 16-7 record (69.6%).

Houston went 0-3 outright in its most recent series versus St.

Louis, but the Over went 3-0 over the set.

Meanwhile, the Guardians defeating the Orioles on Sunday is a good sign for the total being eclipsed on Monday.

That's because the Over has hit in each of Cleveland's last six games following a victory.

How to make Guardians vs.

Astros picks
After simulating every pitch of Astros vs.

Guardians 10,000 times, the model also says one side of the money line has all the value.

You can get that pick at SportsLine .

So who wins Guardians vs.

Astros, and which side of the money line has all the value?

Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks , and find out.